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Article

Cell type-selective disease-association of genes under high regulatory load.

Nucleic acids research - 15 Oct 2015

Galhardo Mafalda, Berninger Philipp, Nguyen Thanh-Phuong, Sauter Thomas, Sinkkonen Lasse

Abstract excerpt

We previously showed that disease-linked metabolic genes are often under combinatorial regulation. Using the genome-wide ChIP-Seq binding profiles for 93 transcription factors in nine different cell lines, we show that genes under high regulatory load are significantly enriched for disease-associ...

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Identifiers

PMID: 26338775
DOI: 10.1093/nar/gkv863
PMCID: PMC4605313

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-26338775-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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