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Article

CD8 T cell response and evolutionary pressure to HIV-1 cryptic epitopes derived from antisense transcription

11 Jan 2010

Abstract excerpt

Retroviruses pack multiple genes into relatively small genomes by encoding several genes in the same genomic region with overlapping reading frames. Both sense and antisense HIV-1 transcripts contain open reading frames for known functional proteins as well as numerous alternative reading frames (ARFs). At least some ARFs have the potential to encode proteins of unknown function, and their antigenic properties...

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PMID: 20065064
DOI: 10.1084/jem.20092060

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