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Article

Mutation of the BRCA1 SQ-cluster results in aberrant mitosis, reduced homologous recombination, and a compensatory increase in non-homologous end joining.

Oncotarget - 29 Sept 2015

Beckta Jason M, Dever Seth M, Gnawali Nisha, Khalil Ashraf, Sule Amrita, Golding Sarah E, Rosenberg Elizabeth, Narayanan Aarthi, Kehn-Hall Kylene, Xu Bo, Povirk Lawrence F, Valerie Kristoffer

Abstract excerpt

Mutations in the breast cancer susceptibility 1 (BRCA1) gene are catalysts for breast and ovarian cancers. Most mutations are associated with the BRCA1 N- and C-terminal domains linked to DNA double-strand break (DSB) repair. However, little is known about the role of the intervening serine-gluta...

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Source

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Identifiers

PMID: 26320175
DOI: 10.18632/oncotarget.4876
PMCID: PMC4695017

Genes

BRCA1
ATM
ATR
PALB2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-26320175-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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