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Article

CSB interacts with BRCA1 in late S/G2 to promote MRN- and CtIP-mediated DNA end resection

4 Sept 2019

Abstract excerpt

CSB, a member of the SWI2/SNF2 superfamily, has been implicated in evicting histones to promote the DSB pathway choice towards homologous recombination (HR) repair. However, how CSB promotes HR repair remains poorly characterized. Here we demonstrate that CSB interacts with both MRE11/RAD50/NBS1 (MRN) and BRCA1 in a cell cycle regulated manner, with the former requiring its WHD and occurring predominantly in...

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PMID: 31501894
DOI: 10.1093/nar/gkz784

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