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Article

Requirement of ATM-dependent phosphorylation of brca1 in the DNA damage response to double-strand breaks.

Science (New York, N.Y.) - 5 Nov 1999

Cortez D, Wang Y, Qin J, Elledge S J

Abstract excerpt

The Brca1 (breast cancer gene 1) tumor suppressor protein is phosphorylated in response to DNA damage. Results from this study indicate that the checkpoint protein kinase ATM (mutated in ataxia telangiectasia) was required for phosphorylation of Brca1 in response to ionizing radiation. ATM resides in a complex with Brca1 and phosphorylated Brca1 in vivo and in vitro in a region that contains clusters of...

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Source

Identifiers

PMID: 10550055
DOI: 10.1126/science.286.5442.1162

Genes

ATM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Requirement of ATM-dependent phosphorylation of brca1 in the DNA damage response to double-strand breaks.PMID 10550055Read ↗

A subset of ATM- and ATR-dependent phosphorylation events requires the BRCA1 protein.Semantic proximity Read ↗

The ATM-dependent DNA damage signaling pathway.Semantic proximity Read ↗

Threonine 68 is required for radiation-induced phosphorylation and activation of Cds1.Semantic proximity Read ↗

Phosphorylation of ATR-interacting protein on Ser239 mediates an interaction with breast-ovarian cancer susceptibility 1 and checkpoint function.Semantic proximity Read ↗

Phosphorylation of serine 1387 in Brca1 is specifically required for the Atm-mediated S-phase checkpoint after ionizing irradiation.Semantic proximity Read ↗

Phosphorylation of SMC1 is a critical downstream event in the ATM-NBS1-BRCA1 pathway.Semantic proximity Read ↗

ATM and genome maintenance: defining its role in breast cancer susceptibility.Semantic proximity Read ↗

Autophosphorylation at serine 1981 stabilizes ATM at DNA damage sites.Semantic proximity Read ↗

Constitutive association of BRCA1 and c-Abl and its ATM-dependent disruption after irradiation.Semantic proximity Read ↗

ATM-dependent and -independent dynamics of the nuclear phosphoproteome after DNA damage.Semantic proximity Read ↗

BRCA1 phosphorylation by Aurora-A in the regulation of G2 to M transition.Semantic proximity Read ↗

Impaired skin and mammary gland development and increased gamma-irradiation-induced tumorigenesis in mice carrying a mutation of S1152-ATM phosphorylation site in Brca1.Semantic proximity Read ↗

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