Article
Mutations in the BRCT binding site of BRCA1 result in hyper-recombination.
Aging - 1 May 2011
Dever Seth M, Golding Sarah E, Rosenberg Elizabeth, Adams Bret R, Idowu Michael O, Quillin John M, Valerie Nicholas, Xu Bo, Povirk Lawrence F, Valerie Kristoffer
Abstract excerpt
We introduced a K1702M mutation in the BRCA1 BRCT domain known to prevent the binding of proteins harboring pS-X-X-F motifs such as Abraxas-RAP80, BRIP1, and CtIP. Surprisingly, rather than impairing homologous recombination repair (HRR), expression of K1702M resulted in hyper-recombination coinciding with an accumulation of cells in S-G2 and no effect on nonhomologous end-joining. These cells also showed...
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