Article
A subset of ATM- and ATR-dependent phosphorylation events requires the BRCA1 protein.
The EMBO journal - 2 Jun 2003
Foray Nicolas, Marot Didier, Gabriel Anastasia, Randrianarison Voahangy, Carr Antony M, Perricaudet Michel, Ashworth Alan, Jeggo Penny
Abstract excerpt
BRCA1 is a central component of the DNA damage response mechanism and defects in BRCA1 confer sensitivity to a broad range of DNA damaging agents. BRCA1 is required for homologous recombination and DNA damage-induced S and G(2)/M phase arrest. We show here that BRCA1 is required for ATM- and ATR-dependent phosphorylation of p53, c-Jun, Nbs1 and Chk2 following exposure to ionizing or ultraviolet radiation,...
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