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Article

Distinct domains in Nbs1 regulate irradiation-induced checkpoints and apoptosis

7 May 2007

Abstract excerpt

The chromosomal instability syndromes Nijmegen breakage syndrome (NBS) and ataxia telangiectasia (AT) share many overlapping phenotypes, including cancer predisposition, radiation sensitivity, cell-cycle checkpoint defects, immunodeficiency, and gonadal dysfunction. The NBS protein Nbs1 is not only a downstream target of AT mutated (ATM) kinase but also acts upstream, promoting optimal ATM activation, ATM...

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PMID: 17485521
DOI: 10.1084/jem.20070319

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