Article
The Impact of a Non-Functional Thyroid Receptor Beta upon Triiodotironine-Induced Cardiac Hypertrophy in Mice.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology - 1 Jan 2015
do Império Güínever Eustáquio, Ramos Isalira Peroba, Santiago Letícia Aragão, Pereira Guilherme Faria, dos Santos Almeida Norma Aparecida, Fuziwara Cesar Seigi, Pazos-Moura Carmen C, Kimura Edna Teruko, Olivares Emerson Lopes, Ortiga-Carvalho Tania Maria
Abstract excerpt
BACKGROUND/AIMS: Thyroid hormone (TH) signalling is critical for heart function. The heart expresses thyroid hormone receptors (THRs); THRα1 and THRβ1. We aimed to investigate the regulation mechanisms of the THRβ isoform, its association with gene expression changes and implications for cardiac function. METHODS: The experiments were performed using adult male mice expressing TRβΔ337T, which contains the Δ337T...
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