Article
Cardiac-specific elevations in thyroid hormone enhance contractility and prevent pressure overload-induced cardiac dysfunction.
Proceedings of the National Academy of Sciences of the United States of America - 11 Apr 2006
Trivieri Maria Giovanna, Oudit Gavin Y, Sah Rajan, Kerfant Benoit-Gilles, Sun Hui, Gramolini Anthony O, Pan Yan, Wickenden Alan D, Croteau Walburga, Morreale de Escobar Gabriella, Pekhletski Roman, St Germain Donald, Maclennan David H, Backx Peter H
Abstract excerpt
Thyroid hormone (TH) is critical for cardiac development and heart function. In heart disease, TH metabolism is abnormal, and many biochemical and functional alterations mirror hypothyroidism. Although TH therapy has been advocated for treating heart disease, a clear benefit of TH has yet to be established, possibly because of peripheral actions of TH. To assess the potential efficacy of TH in treating heart...
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