Article
Regulation of thyroid hormone receptor isoforms in physiological and pathological cardiac hypertrophy.
Circulation research - 28 Sept 2001
Kinugawa K, Yonekura K, Ribeiro R C, Eto Y, Aoyagi T, Baxter J D, Camacho S A, Bristow M R, Long C S, Simpson P C
Abstract excerpt
Physiological and pathological cardiac hypertrophy have directionally opposite changes in transcription of thyroid hormone (TH)-responsive genes, including alpha- and beta-myosin heavy chain (MyHC) and sarcoplasmic reticulum Ca(2+)-ATPase (SERCA), and TH treatment can reverse molecular and functional abnormalities in pathological hypertrophy, such as pressure overload. These findings suggest relative...
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