Article
Altered cardiac phenotype in transgenic mice carrying the delta337 threonine thyroid hormone receptor beta mutant derived from the S family.
Endocrinology - 1 Feb 1999
Gloss B, Sayen M R, Trost S U, Bluhm W F, Meyer M, Swanson E A, Usala S J, Dillmann W H
Abstract excerpt
The heart has been recognized as a major target of thyroid hormone action. Our study investigates both the regulation of cardiac-specific genes and contractile behavior of the heart in the presence of a mutant thyroid hormone receptor beta1 (T3Rbeta1-delta337T) derived from the S kindred. The mut...
Topics
- Animals
- Calcium-Transporting ATPases
- Drug Resistance
- Electrocardiography
- Female
- Gene Dosage
- Gene Expression
- Heart
- Mice
- Mice, Inbred BALB C
- Mice, Transgenic
- Mutation
- Myocardial Contraction
- Myosin Heavy Chains
- Phenotype