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Article

Altered cardiac phenotype in transgenic mice carrying the delta337 threonine thyroid hormone receptor beta mutant derived from the S family.

Endocrinology - 1 Feb 1999

Gloss B, Sayen M R, Trost S U, Bluhm W F, Meyer M, Swanson E A, Usala S J, Dillmann W H

Abstract excerpt

The heart has been recognized as a major target of thyroid hormone action. Our study investigates both the regulation of cardiac-specific genes and contractile behavior of the heart in the presence of a mutant thyroid hormone receptor beta1 (T3Rbeta1-delta337T) derived from the S kindred. The mutant receptor was originally identified in a patient with generalized resistance to thyroid hormone. Cardiac expression...

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PMID: 9927321
DOI: 10.1210/endo.140.2.6527

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