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Article

Gene expression of T3-regulated genes in a mouse model of the human thyroid hormone resistance.

Life sciences - 1 Feb 2017

Santiago L A, Faustino L C, Pereira G F, Imperio G E, Pazos-Moura C C, Wondisford F E, Bloise F F, Ortiga-Carvalho T M

Abstract excerpt

AIMS: To understand how thyroid hormone (TH) regulates tissue-specific gene expression in patients with the syndrome of resistance to TH (RTHβ), we used a mouse model that replicates the human RTHβ, specifically the ∆337T mutation in the thyroid hormone receptor β (THRβ). MAIN METHODS: We investigated the expression of key TH target genes in the pituitary and liver of TRβ∆337T and wild type THRβ mice by qPCR...

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Source

Identifiers

PMID: 27919825
DOI: 10.1016/j.lfs.2016.11.032

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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