Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Characterization of (+/-)-bufuralol hydroxylation activities in liver microsomes of Japanese and Caucasian subjects genotyped for CYP2D6.

Pharmacogenetics - 1 Mar 2001

Shimada T, Tsumura F, Yamazaki H, Guengerich F P, Inoue K

Abstract excerpt

Twenty-four genetic polymorphisms in the CYP2D6 gene were analysed in liver DNA samples of 39 Japanese and 44 Caucasians and compared with CYP2D6 protein levels and bufuralol 1'- and 6-hydroxylation activities in liver microsomes of these human samples. We detected 13 types of CYP2D6 genetic poly...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Catalysis
Share to Cytochrome P-450 CYP2D6
Share to Ethanolamines

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hydroxylation

Share to Microsomes, Liver

Share to Recombinant Proteins

Share to White People

Source

Identifiers

PMID: 11266079
DOI: 10.1097/00008571-200103000-00005

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026. Prepared record publication-11266079-2026-08-31.1. Manifest publication-graph-cohort-2026-08-31.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 31 Aug 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Characterization of (+/-)-bufuralol hydroxylation activities in liver microsomes of Japanese and Caucasian subjects genotyped for CYP2D6.PMID 11266079Read ↗

CYP2D6.10 present in human liver microsomes shows low catalytic activity and thermal stability.Semantic proximity Read ↗

Effects of 22 Novel CYP2D6 Variants Found in the Chinese Population on the Bufuralol and Dextromethorphan Metabolisms In Vitro.Semantic proximity Read ↗

The decreased in vivo clearance of CYP2D6 substrates by CYP2D6*10 might be caused not only by the low-expression but also by low affinity of CYP2D6.Semantic proximity Read ↗

Evaluation of CYP2D6 Protein Expression and Activity in the Small Intestine to Determine Its Metabolic Capability in the Japanese Population.Semantic proximity Read ↗

In vitro functional assessment of 22 newly identified CYP2D6 allelic variants in the Chinese population.Semantic proximity Read ↗

Allele and genotype frequencies of CYP2B6 in a Turkish population.Semantic proximity Read ↗

Comprehensive analysis of the genetic factors determining expression and function of hepatic CYP2D6.Semantic proximity Read ↗

Two novel CYP2D6*10 haplotypes as possible causes of a poor metabolic phenotype in Japanese.Semantic proximity Read ↗

Functional influence of human CYP2D6 allelic variations: P34S, E418K, S486T, and R296C.Semantic proximity Read ↗

Genetic polymorphisms analysis of CYP2D6 in the Uygur population.Semantic proximity Read ↗

Discovery of novel functional variants and extensive evaluation of CYP2D6 genetic polymorphisms in Koreans.Semantic proximity Read ↗

Direct sequencing and comprehensive screening of genetic polymorphisms on CYP2 family genes (CYP2A6, CYP2B6, CYP2C8, and CYP2E1) in five ethnic populations.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.