Article
Characterization of cytochrome P450 2D6.1 (CYP2D6.1), CYP2D6.2, and CYP2D6.17 activities toward model CYP2D6 substrates dextromethorphan, bufuralol, and debrisoquine.
Drug metabolism and disposition: the biological fate of chemicals - 1 May 2002
Marcucci Kenda A, Pearce Robin E, Crespi Charles, Steimel Dorothy T, Leeder J Steven, Gaedigk Andrea
Abstract excerpt
Over 50 allelic variants of cytochrome P450 2D6 (CYP2D6) encoding fully functional, reduced-activity, or nonfunctional proteins have been described. Compared with Caucasians, studies in black populations demonstrate a tendency toward slower CYP2D6 activity, attributed in part to the presence of a variant allele associated with reduced activity, the CYP2D6*17 allele. To investigate the kinetic characteristics of...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.