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Article

Engineering Synthetic cis-Regulatory Elements for Simultaneous Recognition of Three Transcriptional Factors in Bacteria.

ACS synthetic biology - 18 Dec 2015

Amores Gerardo Ruiz, Guazzaroni María-Eugenia, Silva-Rocha Rafael

Abstract excerpt

Recognition of cis-regulatory elements by transcription factors (TF) at target promoters is crucial to gene regulation in bacteria. In this process, binding of TFs to their cognate sequences depends on a set of physical interactions between these proteins and specific nucleotides in the operator region. Previously, we showed that in silico optimization algorithms are able to generate short sequences that are...

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PMID: 26305598
DOI: 10.1021/acssynbio.5b00098

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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