Article
Predictive design of sigma factor-specific promoters.
Nature communications - 16 Nov 2020
Van Brempt Maarten, Clauwaert Jim, Mey Friederike, Stock Michiel, Maertens Jo, Waegeman Willem, De Mey Marjan
Abstract excerpt
To engineer synthetic gene circuits, molecular building blocks are developed which can modulate gene expression without interference, mutually or with the host's cell machinery. As the complexity of gene circuits increases, automated design tools and tailored building blocks to ensure perfect tuning of all components in the network are required. Despite the efforts to develop prediction tools that allow forward...
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