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Article

Broadening the signal specificity of prokaryotic promoters by modifying cis-regulatory elements associated with a single transcription factor.

Molecular bioSystems - 6 Jul 2012

Silva-Rocha Rafael, de Lorenzo Víctor

Abstract excerpt

In this report, we experimentally demonstrate that improving the cis-regulatory region of a target promoter can significantly enhance the response to an otherwise poor inducer. The transcriptional factor (TF) BenR of Pseudomonas putida KT2440 is a member of the AraC/XylS family that activates the Pb promoter in response to benzoate. This TF can also trigger Pb activity in response to 3-methylbenzoate (3MBz), but...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to Regulatory Elements, Transcriptional

Share to Regulatory Sequences, Nucleic Acid

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Source

Identifiers

PMID: 22588473
DOI: 10.1039/c2mb25030f

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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