Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Phenotypic engineering by reprogramming gene transcription using novel artificial transcription factors in Escherichia coli.

Nucleic acids research - 1 Sept 2008

Lee Ju Young, Sung Bong Hyun, Yu Byung Jo, Lee Jun Hyoung, Lee Sang Hee, Kim Mi Sun, Koob Michael D, Kim Sun Chang

Abstract excerpt

Now that many genomes have been sequenced and the products of newly identified genes have been annotated, the next goal is to engineer the desired phenotypes in organisms of interest. For the phenotypic engineering of microorganisms, we have developed novel artificial transcription factors (ATFs) capable of reprogramming innate gene expression circuits in Escherichia coli. These ATFs are composed of zinc finger...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cyclic AMP Receptor Protein
Share to Escherichia coli Proteins

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Bacterial

Share to Gene Library

Share to Genetic Engineering

Share to Industrial Microbiology

Share to Protein Engineering

Share to Zinc Fingers

Source

Open in PubMed Open full text

Identifiers

PMID: 18641039
DOI: 10.1093/nar/gkn449
PMCID: PMC2532725

Genes

CRP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Phenotypic engineering by reprogramming gene transcription using novel artificial transcription factors in Escherichia coli.PMID 18641039Read ↗

Phenotypic alteration and target gene identification using combinatorial libraries of zinc finger proteins in prokaryotic cells.Semantic proximity Read ↗

Phenotypic alteration of eukaryotic cells using randomized libraries of artificial transcription factors.Semantic proximity Read ↗

Laboratory Evolution Reveals Transcriptional Mechanisms Underlying Thermal Adaptation of Escherichia coli.Semantic proximity Read ↗

Insightful directed evolution of Escherichia coli quorum sensing promoter region of the lsrACDBFG operon: a tool for synthetic biology systems and protein expression.Semantic proximity Read ↗

Engineering transcription factors with novel DNA-binding specificity using comparative genomics.Semantic proximity Read ↗

Artificial gene amplification reveals an abundance of promiscuous resistance determinants in Escherichia coli.Semantic proximity Read ↗

Using transcription machinery engineering to elicit complex cellular phenotypes.Semantic proximity Read ↗

Development of transcriptional factor-based whole-cell biosensors to monitor and degrade antibiotics using mutant cells obtained via adaptive laboratory evolution.Semantic proximity Read ↗

Engineering an allosteric transcription factor to respond to new ligands.Semantic proximity Read ↗

Non-transcriptional regulatory processes shape transcriptional network dynamics.Semantic proximity Read ↗

Pervasive gene deregulation underlies adaptation and maladaptation in trimethoprim-resistant E. coli.Semantic proximity Read ↗

Random sequences rapidly evolve into de novo promoters.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.