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Article

A quantitative method for proteome reallocation using minimal regulatory interventions.

Nature chemical biology - 1 Sept 2020

Lastiri-Pancardo Gustavo, Mercado-Hernández Jonathan S, Kim Juhyun, Jiménez José I, Utrilla José

Abstract excerpt

Engineering resource allocation in biological systems is an ongoing challenge. Organisms allocate resources for ensuring survival, reducing the productivity of synthetic biology functions. Here we present a new approach for engineering the resource allocation of Escherichia coli by rationally modifying its transcriptional regulatory network. Our method (ReProMin) identifies the minimal set of genetic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32661378
DOI: 10.1038/s41589-020-0593-y

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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