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Article

Plasticity of the cis-regulatory input function of a gene.

PLoS biology - 1 Apr 2006

Mayo Avraham E, Setty Yaakov, Shavit Seagull, Zaslaver Alon, Alon Uri

Abstract excerpt

The transcription rate of a gene is often controlled by several regulators that bind specific sites in the gene's cis-regulatory region. The combined effect of these regulators is described by a cis-regulatory input function. What determines the form of an input function, and how variable is it with respect to mutations? To address this, we employ the well-characterized lac operon of Escherichia coli, which has...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Bacterial

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Share to Promoter Regions, Genetic

Share to Regulatory Elements, Transcriptional

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Identifiers

PMID: 16602820
DOI: 10.1371/journal.pbio.0040045
PMCID: PMC1413569

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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