Article
Vitamin D and Risk of Multiple Sclerosis: A Mendelian Randomization Study.
PLoS medicine - 1 Aug 2015
Mokry Lauren E, Ross Stephanie, Ahmad Omar S, Forgetta Vincenzo, Smith George Davey, Goltzman David, Leong Aaron, Greenwood Celia M T, Thanassoulis George, Richards J Brent
Abstract excerpt
BACKGROUND: Observational studies have demonstrated an association between decreased vitamin D level and risk of multiple sclerosis (MS); however, it remains unclear whether this relationship is causal. We undertook a Mendelian randomization (MR) study to evaluate whether genetically lowered vitamin D level influences the risk of MS. METHODS AND FINDINGS: We identified single nucleotide polymorphisms (SNPs)...
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