Article
Evidence for a causal relationship between low vitamin D, high BMI, and pediatric-onset MS.
Neurology - 25 Apr 2017
Gianfrancesco Milena A, Stridh Pernilla, Rhead Brooke, Shao Xiaorong, Xu Edison, Graves Jennifer S, Chitnis Tanuja, Waldman Amy, Lotze Timothy, Schreiner Teri, Belman Anita, Greenberg Benjamin, Weinstock-Guttman Bianca, Aaen Gregory, Tillema Jan M, Hart Janace, Caillier Stacy, Ness Jayne, Harris Yolanda, Rubin Jennifer, Candee Meghan, Krupp Lauren, Gorman Mark, Benson Leslie, Rodriguez Moses, Mar Soe, Kahn Ilana, Rose John, Roalstad Shelly, Casper T Charles, Shen Ling, Quach Hong, Quach Diana, Hillert Jan, Bäärnhielm Maria, Hedstrom Anna, Olsson Tomas, Kockum Ingrid, Alfredsson Lars, Metayer Catherine, Schaefer Catherine, Barcellos Lisa F, Waubant Emmanuelle
Abstract excerpt
OBJECTIVE: To utilize Mendelian randomization to estimate the causal association between low serum vitamin D concentrations, increased body mass index (BMI), and pediatric-onset multiple sclerosis (MS) using genetic risk scores (GRS). METHODS: We constructed an instrumental variable for vitamin D (vitD GRS) by computing a GRS for 3 genetic variants associated with levels of 25(OH)D in serum using the estimated...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.