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Article

BMI and low vitamin D are causal factors for multiple sclerosis: A Mendelian Randomization study.

Neurology(R) neuroimmunology & neuroinflammation - 1 Mar 2020

Jacobs Benjamin M, Noyce Alastair J, Giovannoni Gavin, Dobson Ruth

Abstract excerpt

OBJECTIVE: To update the causal estimates for the effects of adult body mass index (BMI), childhood BMI, and vitamin D status on multiple sclerosis (MS) risk. METHODS: We used 2-sample Mendelian randomization to determine causal estimates. Summary statistics for SNP associations with traits of interest were obtained from the relevant consortia. Primary analyses consisted of random-effects...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 31937597
DOI: 10.1212/NXI.0000000000000662
PMCID: PMC6975169

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