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Mendelian randomization in multiple sclerosis: A causal role for vitamin D and obesity?

1 Jan 2018

Abstract excerpt

The etiology of multiple sclerosis (MS) involves a complex interplay of genetic and environmental factors. Epidemiologic studies have furthered our understanding of these risk factors but remain limited by residual confounding and potential for reverse causation, particularly in MS where time of disease onset is not known. Mendelian randomization (MR) uses genetic variants to study the causal effect of modifiable...

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PMID: 29307294
DOI: 10.1177/1352458517737373

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