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Mendelian randomization shows a causal effect of low vitamin D on multiple sclerosis risk

14 Sept 2016

Abstract excerpt

OBJECTIVE: We sought to estimate the causal effect of low serum 25(OH)D on multiple sclerosis (MS) susceptibility that is not confounded by environmental or lifestyle factors or subject to reverse causality. METHODS: We conducted mendelian randomization (MR) analyses using an instrumental variable (IV) comprising 3 single nucleotide polymorphisms found to be associated with serum 25(OH)D levels at genome-wide...

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PMID: 27652346
DOI: 10.1212/nxg.0000000000000097

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