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Article

Spurious intragenic transcription is a feature of mammalian cellular senescence and tissue aging.

Nature aging - 1 Apr 2023

Sen Payel, Donahue Greg, Li Catherine, Egervari Gabor, Yang Na, Lan Yemin, Robertson Neil, Shah Parisha P, Kerkhoven Erik, Schultz David C, Adams Peter D, Berger Shelley L

Abstract excerpt

Mammalian aging is characterized by the progressive loss of tissue function and increased risk for disease. Accumulation of senescent cells in aging tissues partly contributes to this decline, and targeted depletion of senescent cells in vivo ameliorates many age-related phenotypes. The fundamental molecular mechanisms responsible for the decline of cellular health and fitness during senescence and aging are...

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PMID: 37117791
DOI: 10.1038/s43587-023-00384-3
PMCID: PMC10165726

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