Article

Spurious intragenic transcription is a hallmark of mammalian cellular senescence and tissue aging

2022-05-22

Abstract excerpt

Mammalian aging is characterized by the progressive loss of tissue integrity and function manifesting in ill health and increased risk for developing multiple chronic conditions. Accumulation of senescent cells in aging tissues partly contributes to this decline and targeted depletion of senescent cells in vivo ameliorates many age-related phenotypes. However, the fundamental molecular mechanisms responsible for...

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Literature Corpus work: 78380c7a-15f7-5b39-a12c-17282abe86c8
DOI: 10.1101/2022.05.20.492816

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