Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The landscape of transcription errors in eukaryotic cells.

Science advances - 1 Oct 2017

Gout Jean-Francois, Li Weiyi, Fritsch Clark, Li Annie, Haroon Suraiya, Singh Larry, Hua Ding, Fazelinia Hossein, Smith Zach, Seeholzer Steven, Thomas Kelley, Lynch Michael, Vermulst Marc

Abstract excerpt

Accurate transcription is required for the faithful expression of genetic information. To understand the molecular mechanisms that control the fidelity of transcription, we used novel sequencing technology to provide the first comprehensive analysis of the fidelity of transcription in eukaryotic cells. Our results demonstrate that transcription errors can occur in any gene, at any location, and affect every...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to 3' Untranslated Regions
Share to DNA-Directed RNA Polymerases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Eukaryotic Cells

Share to Mutagenesis

Share to Mutation Rate

Share to Nonsense Mediated mRNA Decay

Share to Protein Subunits

Share to Yeasts

Source

Open in PubMed Open full text

Identifiers

PMID: 29062891
DOI: 10.1126/sciadv.1701484
PMCID: PMC5650487

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The landscape of transcription errors in eukaryotic cells.PMID 29062891Read ↗

Evolutionary conservation of the fidelity of transcriptionSemantic proximity Read ↗

RNA polymerase errors cause splicing defects and can be regulated by differential expression of RNA polymerase subunits.Semantic proximity Read ↗

Genome-wide surveillance of transcription errors in response to genotoxic stress.Semantic proximity Read ↗

Error-prone DNA polymerases: when making a mistake is the only way to get ahead.Semantic proximity Read ↗

Transcription errors induce proteotoxic stress and shorten cellular lifespan.Semantic proximity Read ↗

Universally high transcript error rates in bacteria.Semantic proximity Read ↗

Isolation and characterization of transcription fidelity mutants.Semantic proximity Read ↗

Lost in transcription: transient errors in information transfer.Semantic proximity Read ↗

Accurate RNA consensus sequencing for high-fidelity detection of transcriptional mutagenesis-induced epimutations.Semantic proximity Read ↗

Oxidative stress drives mutagenesis through transcription coupled repair in bacteriaSemantic proximity Read ↗

A Genome-Wide Assay Specifies Only GreA as a Transcription Fidelity Factor in Escherichia coli.Semantic proximity Read ↗

The fidelity of transcription in human cellsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.