Article

Circulating chromatin reveals the effects of disease-associated variants on gene regulation

2025-11-13

Abstract excerpt

A fundamental challenge in human genetics is determining how variation in regulatory DNA shapes complex traits and disease risk. Chromatin quantitative trait loci (cQTLs) can address this challenge by revealing the effects of disease-linked genetic variants on regulatory element activity. Discovering cQTLs in disease-relevant tissues at scale remains challenging, however. To address this limitation, we leveraged a...

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Literature Corpus work: c842c79a-bfd5-50b9-a05c-d8be034326ce
DOI: 10.1101/2025.11.12.688010

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