Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Regional mosaic genomic heterogeneity in the elderly and in Alzheimer's disease as a correlate of neuronal vulnerability.

Acta neuropathologica - 1 Oct 2015

Arendt Thomas, Brückner Martina K, Lösche Andreas

Abstract excerpt

Alzheimer's disease (AD) is a neurodegenerative disorder characterized by fibrillary aggregates of Aβ peptide and tau protein. The distribution of these pathological hallmarks throughout the brain is not random; it follows a predictive pattern that is used for pathological staging. However, most etiopathogenetic concepts, irrespective of whether they focus on Aβ or tau pathology, leave a key question unanswered:...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged
Share to Aged, 80 and over
Share to Aging

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Alzheimer Disease

Share to Cerebral Cortex

Share to Genetic Variation

Share to Neurons

Source

Identifiers

PMID: 26298468
DOI: 10.1007/s00401-015-1465-5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Regional mosaic genomic heterogeneity in the elderly and in Alzheimer's disease as a correlate of neuronal vulnerability.PMID 26298468Read ↗

Region- and Cell-specific Aneuploidy in Brain Aging and NeurodegenerationSemantic proximity Read ↗

Aneuploidy-driven non-heritable genomic variations demonstrate area-specific distribution in the Alzheimer’s disease brainSemantic proximity Read ↗

The DNA Replication Stress Hypothesis of Alzheimer’s DiseaseSemantic proximity Read ↗

Mosaic chromosomal alterations in blood are associated with an increased risk of Alzheimer’s diseaseSemantic proximity Read ↗

DNA damage and senescence in the aging and Alzheimer’s disease cortex are not uniformly distributedSemantic proximity Read ↗

Review: Somatic mutations in neurodegeneration.Semantic proximity Read ↗

Genome instability in Alzheimer disease.Semantic proximity Read ↗

Somatic copy number variant load in neurons of healthy controls and Alzheimer’s disease patientsSemantic proximity Read ↗

Aneuploidy, chromosomal missegregation, and cell cycle reentry in Alzheimer's disease.Semantic proximity Read ↗

Aneuploidy and DNA replication in the normal human brain and Alzheimer's disease.Semantic proximity Read ↗

Characterization of mitochondrial DNA quantity and quality in the human aged and Alzheimer’s disease brainSemantic proximity Read ↗

Toward an integrated genetic and epigenetic approach to Alzheimer's disease.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.