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Article

Aneuploidy and DNA replication in the normal human brain and Alzheimer's disease.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 27 Jun 2007

Mosch Birgit, Morawski Markus, Mittag Anja, Lenz Dominik, Tarnok Attila, Arendt Thomas

Abstract excerpt

Reactivation of the cell cycle, including DNA replication, might play a major role in Alzheimer's disease (AD). A more than diploid DNA content in differentiated neurons might alternatively result from chromosome mis-segregation during mitosis in neuronal progenitor cells. It was our objective to distinguish between these two mechanisms for aneuploidy and to provide evidence for a functional cell cycle in AD....

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Identifiers

PMID: 17596434
DOI: 10.1523/JNEUROSCI.0379-07.2007
PMCID: PMC6672221

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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