Article
Genome instability in Alzheimer disease.
Mechanisms of ageing and development - 1 Jan 2017
Hou Yujun, Song Hyundong, Croteau Deborah L, Akbari Mansour, Bohr Vilhelm A
Abstract excerpt
Alzheimer's disease (AD) is a progressive neurodegenerative disorder and the most common form of dementia. Autosomal dominant, familial AD (fAD) is very rare and caused by mutations in amyloid precursor protein (APP), presenilin-1 (PSEN-1), and presenilin-2 (PSEN-2) genes. The pathogenesis of sporadic AD (sAD) is more complex and variants of several genes are associated with an increased lifetime risk of AD....
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