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Region- and Cell-specific Aneuploidy in Brain Aging and Neurodegeneration

9 Feb 2018

Abstract excerpt

Variations in genomic DNA content, or aneuploidy, are a well-recognized feature of normal human brain development. Whether changes in the levels of aneuploidy are a factor in Alzheimer's disease (AD) is less clear, as the data reported to date vary substantially in the levels of aneuploidy detected (0.7-11.5%), possibly due to methodological limitations, but also influenced by individual, regional and cellular...

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PMID: 29432756
DOI: 10.1016/j.neuroscience.2018.01.050

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