Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Hypomethylation within gene promoter regions and type 1 diabetes in discordant monozygotic twins.

Journal of autoimmunity - 1 Apr 2016

Elboudwarej Emon, Cole Michael, Briggs Farren B S, Fouts Alexandra, Fain Pamela R, Quach Hong, Quach Diana, Sinclair Elizabeth, Criswell Lindsey A, Lane Julie A, Steck Andrea K, Barcellos Lisa F, Noble Janelle A

Abstract excerpt

Genetic susceptibility to type 1 diabetes (T1D) is well supported by epidemiologic evidence; however, disease risk cannot be entirely explained by established genetic variants identified so far. This study addresses the question of whether epigenetic modification of the inherited DNA sequence may contribute to T1D susceptibility. Using the Infinium HumanMethylation450 BeadChip array (450k), a total of seven...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CpG Islands
Share to Diabetes Mellitus, Type 1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Methylation

Share to Epigenesis, Genetic

Share to Organ Specificity

Share to Promoter Regions, Genetic

Share to Reproducibility of Results

Share to Twins, Monozygotic

Source

Open in PubMed Open full text

Identifiers

PMID: 26782299
DOI: 10.1016/j.jaut.2015.12.003
PMCID: PMC4792657

Genes

NTS
BACH2
FANCC
IGF2
INS
MAGI2
PCDHB16

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Hypomethylation within gene promoter regions and type 1 diabetes in discordant monozygotic twins.PMID 26782299Read ↗

DNA methylation profiles in type 1 diabetes twins point to strong epigenetic effects on etiology.Semantic proximity Read ↗

Increased DNA methylation variability in type 1 diabetes across three immune effector cell typesSemantic proximity Read ↗

Identification of type 1 diabetes-associated DNA methylation variable positions that precede disease diagnosis.Semantic proximity Read ↗

Identification of loci where DNA methylation potentially mediates genetic risk of type 1 diabetes.Semantic proximity Read ↗

Extensive variation and low heritability of DNA methylation identified in a twin study.Semantic proximity Read ↗

An integrated epigenomic analysis for type 2 diabetes susceptibility loci in monozygotic twins.Semantic proximity Read ↗

Global analysis of DNA methylation variation in adipose tissue from twins reveals links to disease-associated variants in distal regulatory elements.Semantic proximity Read ↗

Novel epigenetic determinants of type 2 diabetes in Mexican-American families.Semantic proximity Read ↗

Genetic and epigenetic factors in etiology of diabetes mellitus type 1.Semantic proximity Read ↗

Genome-wide survey reveals predisposing diabetes type 2-related DNA methylation variations in human peripheral blood.Semantic proximity Read ↗

Allele-specific methylation of type 1 diabetes susceptibility genes.Semantic proximity Read ↗

Genome-wide analysis of DNA methylation in hypertension-discordant monozygotic twinsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.