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Article

DNA methylation and mRNA expression of HLA-DQA1 alleles in type 1 diabetes mellitus.

Immunology - 1 Jun 2016

Cepek Pavel, Zajacova Marta, Kotrbova-Kozak Anna, Silhova Elena, Cerna Marie

Abstract excerpt

Type 1 diabetes (T1D) belongs among polygenic multifactorial autoimmune diseases. The highest risk is associated with human leucocyte antigen (HLA) class II genes, including HLA-DQA1 gene. Our aim was to investigate DNA methylation of HLA-DQA1 promoter alleles (QAP) and correlate methylation status with individual HLA-DQA1 allele expression of patients with T1D and healthy controls. DNA methylation is one of the...

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Identifiers

PMID: 26854762
DOI: 10.1111/imm.12593
PMCID: PMC4863572

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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