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Article

Allele-specific methylation of type 1 diabetes susceptibility genes.

Journal of autoimmunity - 1 May 2018

Kindt Alida S D, Fuerst Rainer W, Knoop Jan, Laimighofer Michael, Telieps Tanja, Hippich Markus, Woerheide Maria A, Wahl Simone, Wilson Rory, Sedlmeier Eva-Maria, Hommel Angela, Todd John A, Krumsiek Jan, Ziegler Anette-G, Bonifacio Ezio

Abstract excerpt

The susceptibility to autoimmune diseases is influenced by genes encoding major histocompatibility complex (MHC) proteins. By examining the epigenetic methylation maps of cord blood samples, we found marked differences in the methylation status of CpG sites within the MHC genes (cis-metQTLs) between carriers of the type 1 diabetes risk haplotypes HLA-DRB1*03-DQA1*0501-DQB1*0201 (DR3-DQ2) and...

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Identifiers

PMID: 29224923
DOI: 10.1016/j.jaut.2017.11.008

Genes

LDHC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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