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Article

The role of DNA methylation in the regulation of HLA expression.

Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia - 1 Sept 2026

Strnad Adam, Petrek Martin

Abstract excerpt

DNA methylation plays a critical role in the regulation of gene expression in the human leukocyte antigen (HLA) system which is a key component of immune function. This article reviews the molecular mechanisms by which DNA methylation influences HLA gene regulation, highlighting its impact on their antigen presentation and immune tolerance functions. We describe how methylation patterns vary in HLA class I and II...

Read the complete abstract on PubMed

Topics

Humans
DNA Methylation
HLA Antigens
Polymorphism, Single Nucleotide
Epigenesis, Genetic
Gene Expression Regulation

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

CpG Islands

Autoimmune Diseases

Source

Identifiers

PMID: 41334876
DOI: 10.5507/bp.2025.031

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 18 Oct 2026.

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