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Article

Genetic and Informatic Analyses Implicate Kif12 as a Candidate Gene within the Mpkd2 Locus That Modulates Renal Cystic Disease Severity in the Cys1cpk Mouse.

PloS one - 1 Jan 2015

Mrug Michal, Zhou Juling, Yang Chaozhe, Aronow Bruce J, Cui Xiangqin, Schoeb Trenton R, Siegal Gene P, Yoder Bradley K, Guay-Woodford Lisa M

Abstract excerpt

We have previously mapped the interval on Chromosome 4 for a major polycystic kidney disease modifier (Mpkd) of the B6(Cg)-Cys1cpk/J mouse model of recessive polycystic kidney disease (PKD). Informatic analyses predicted that this interval contains at least three individual renal cystic disease severity-modulating loci (Mpkd1-3). In the current study, we provide further validation of these predicted effects using...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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PMID: 26295839
DOI: 10.1371/journal.pone.0135678
PMCID: PMC4546649

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Source receipt: pubmed, retrieved 7 Sept 2026.

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