Localization of a murine recessive polycystic kidney disease mutation and modifying loci that affect disease severity.

doi:10.1016/0888-7543(95)80088-4

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Article

Localization of a murine recessive polycystic kidney disease mutation and modifying loci that affect disease severity.

Genomics - 1 Mar 1995

Iakoubova O A, Dushkin H, Beier D R

Abstract excerpt

We have used a novel method of chromosomal exclusion to map the recessive mutation juvenile cystic kidney (jck) to mouse chromosome 11 using an intercross between (C57BL/6J x DBA/2J) F1jck/ + mice. The severity of polycystic kidney disease (PKD) in the intercross progeny was significantly more va...

Topics

Animals
Chromosome Mapping
Crosses, Genetic
DNA, Satellite
Genetic Linkage
Genetic Markers
Mice
Mice, Inbred C57BL
Mice, Inbred DBA
Mice, Mutant Strains
Mutation
Organ Size
Polycystic Kidney, Autosomal Recessive

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