Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Localization of a murine recessive polycystic kidney disease mutation and modifying loci that affect disease severity.

Genomics - 1 Mar 1995

Iakoubova O A, Dushkin H, Beier D R

Abstract excerpt

We have used a novel method of chromosomal exclusion to map the recessive mutation juvenile cystic kidney (jck) to mouse chromosome 11 using an intercross between (C57BL/6J x DBA/2J) F1jck/ + mice. The severity of polycystic kidney disease (PKD) in the intercross progeny was significantly more variable than that found in the parental C57BL/6J strain, suggesting that a modifier locus or loci introduced from DBA/2J...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chromosome Mapping
Share to Crosses, Genetic
Share to Genetic Linkage

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genetic Markers

Share to Mice, Inbred C57BL

Share to Mice, Mutant Strains

Share to Mutation

Source

Identifiers

PMID: 7782068
DOI: 10.1016/0888-7543(95)80088-4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Localization of a murine recessive polycystic kidney disease mutation and modifying loci that affect disease severity.PMID 7782068Read ↗

Genetic analysis of a quantitative trait in a mouse model of polycystic kidney disease.Semantic proximity Read ↗

Genetic analysis of modifying loci on mouse chromosome 1 that affect disease severity in a model of recessive PKD.Semantic proximity Read ↗

High-resolution genetic localization of a modifying locus affecting disease severity in the juvenile cystic kidneys (jck) mouse model of polycystic kidney disease.Semantic proximity Read ↗

Genetic localization of interacting modifiers affecting severity in a murine model of polycystic kidney disease.Semantic proximity Read ↗

Evidence that two phenotypically distinct mouse PKD mutations, bpk and jcpk, are allelic.Semantic proximity Read ↗

Quantitative trait loci modulate renal cystic disease severity in the mouse bpk model.Semantic proximity Read ↗

Genetic identification of two major modifier loci of polycystic kidney disease progression in pcy mice.Semantic proximity Read ↗

Genetic and Informatic Analyses Implicate Kif12 as a Candidate Gene within the Mpkd2 Locus That Modulates Renal Cystic Disease Severity in the Cys1cpk Mouse.Semantic proximity Read ↗

Genetic modifiers of polycystic kidney disease in intersubspecific KAT2J mutants.Semantic proximity Read ↗

Juvenile cystic kidneys (jck): a new mouse mutation which causes polycystic kidneys.Semantic proximity Read ↗

An integrated genetic and physical map of the 650-kb region containing the congenital polycystic kidney (cpk) locus on mouse chromosome 12.Semantic proximity Read ↗

Phenotypic variations of orpk mutation and chromosomal localization of modifiers influencing kidney phenotype.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.