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Article

Quantitative trait loci modulate renal cystic disease severity in the mouse bpk model.

Journal of the American Society of Nephrology : JASN - 1 Jul 2000

Guay-Woodford Lisa M, Wright Christopher J, Walz Gerd, Churchill Gary A

Abstract excerpt

Numerous mouse models of polycystic kidney disease (PKD) have been described in which the mutant phenotypes closely resemble human PKD with regard to morphology, cyst localization, and disease progression. As in human PKD, genetic background affects the disease phenotype in mouse PKD models. Using experimental crosses, these modifying effects can be dissected into discrete genetic factors referred to as...

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Share to Agammaglobulinaemia Tyrosine Kinase
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to GTP-Binding Proteins

Share to Mice, Inbred BALB C

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Source

Identifiers

PMID: 10864581
DOI: 10.1681/ASN.V1171253

Genes

CAST
RGS7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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