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Article

Genetic identification of two major modifier loci of polycystic kidney disease progression in pcy mice.

The Journal of clinical investigation - 15 Oct 1997

Woo D D, Nguyen D K, Khatibi N, Olsen P

Abstract excerpt

Unlike the uniform disease progression in inbred animals, polycystic kidney disease (PKD) progression within human families can be highly variable. This may be due to environmental or genetic factors or both. To determine if PKD severity can be influenced by modifier genes, we carried out an intercross between DBA/2-pcy/pcy and Mus m. castaneous involving 3,105 6-wk-old F2 mice. Large differences in PKD severity...

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Identifiers

PMID: 9329956
DOI: 10.1172/JCI119724
PMCID: PMC508382

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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