Article
Genetic identification of two major modifier loci of polycystic kidney disease progression in pcy mice.
The Journal of clinical investigation - 15 Oct 1997
Woo D D, Nguyen D K, Khatibi N, Olsen P
Abstract excerpt
Unlike the uniform disease progression in inbred animals, polycystic kidney disease (PKD) progression within human families can be highly variable. This may be due to environmental or genetic factors or both. To determine if PKD severity can be influenced by modifier genes, we carried out an inte...
Topics
- Analysis of Variance
- Animals
- Body Weight
- Causality
- Chromosome Mapping
- Crosses, Genetic
- Disease Progression
- Female
- Genetic Variation
- Genotype
- Lod Score
- Male
- Mice
- Mice, Inbred DBA
- Mice, Mutant Strains
- Organ Size
- Phenotype
- Polycystic Kidney Diseases