Karyotype evolution and acquisition of FLT3 or RAS pathway alterations drive progression of myelodysplastic syndrome to acute myeloid leukemia

Abstract excerpt

Myelodysplastic syndromes (MDS) are a heterogeneous group of myeloid neoplasms associated with aberrant myeloid differentiation and ineffective hematopoiesis leading to cytopenias. In more than 20% of affected patients the MDS transforms into secondary acute myeloid leukemia (s-AML). To date, information on the molecular and cytogenetic bases of leukemic transformation into AML are rare and there is a compelling...

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