Article
Molecular, cytogenetic and genetic abnormalities in MDS and secondary AML.
Cancer treatment and research - 1 Jan 2001
Padua R A, McGlynn A, McGlynn H
Abstract excerpt
Myelodysplasia (MDS) is a clonal disease, which increases with age, suggesting that multiple steps are required for the evolution of the condition. Approximately 30% of MDS evolve into acute myelogenous leukemia (AML). In this review, we intend to delineate the genetic events, which may drive this sequence and therefore we will focus primarily on cytogenetic abnormalities where the genes have been identified and...
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