Article
Genome-wide association study identifies HLA 8.1 ancestral haplotype alleles as major genetic risk factors for myositis phenotypes.
Genes and immunity - 1 Oct 2015
Miller F W, Chen W, O'Hanlon T P, Cooper R G, Vencovsky J, Rider L G, Danko K, Wedderburn L R, Lundberg I E, Pachman L M, Reed A M, Ytterberg S R, Padyukov L, Selva-O'Callaghan A, Radstake T R, Isenberg D A, Chinoy H, Ollier W E R, Scheet P, Peng B, Lee A, Byun J, Lamb J A, Gregersen P K, Amos C I
Abstract excerpt
Autoimmune muscle diseases (myositis) comprise a group of complex phenotypes influenced by genetic and environmental factors. To identify genetic risk factors in patients of European ancestry, we conducted a genome-wide association study (GWAS) of the major myositis phenotypes in a total of 1710 cases, which included 705 adult dermatomyositis, 473 juvenile dermatomyositis, 532 polymyositis and 202 adult...
Topics
- Adolescent
- Adult
- Alleles
- Autoantibodies
- Case-Control Studies
- Dermatomyositis
- Female
- Genetic Association Studies
- Genetic Predisposition to Disease