Article
Dense genotyping of immune-related loci in idiopathic inflammatory myopathies confirms HLA alleles as the strongest genetic risk factor and suggests different genetic background for major clinical subgroups.
Annals of the rheumatic diseases - 1 Aug 2016
Rothwell Simon, Cooper Robert G, Lundberg Ingrid E, Miller Frederick W, Gregersen Peter K, Bowes John, Vencovsky Jiri, Danko Katalin, Limaye Vidya, Selva-O'Callaghan Albert, Hanna Michael G, Machado Pedro M, Pachman Lauren M, Reed Ann M, Rider Lisa G, Cobb Joanna, Platt Hazel, Molberg Øyvind, Benveniste Olivier, Mathiesen Pernille, Radstake Timothy, Doria Andrea, De Bleecker Jan, De Paepe Boel, Maurer Britta, Ollier William E, Padyukov Leonid, O'Hanlon Terrance P, Lee Annette, Amos Christopher I, Gieger Christian, Meitinger Thomas, Winkelmann Juliane, Wedderburn Lucy R, Chinoy Hector, Lamb Janine A
Abstract excerpt
OBJECTIVES: The idiopathic inflammatory myopathies (IIMs) are a heterogeneous group of rare autoimmune diseases characterised by muscle weakness and extramuscular manifestations such as skin rashes and interstitial lung disease. We genotyped 2566 IIM cases of Caucasian descent using the Immunochip; a custom array covering 186 established autoimmune susceptibility loci. The cohort was predominantly comprised of...
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