Article
Contribution of Rare Genetic Variation to Disease Susceptibility in a Large Scandinavian Myositis Cohort.
Arthritis & rheumatology (Hoboken, N.J.) - 1 Feb 2022
Bianchi Matteo, Kozyrev Sergey V, Notarnicola Antonella, Hultin Rosenberg Lina, Karlsson Åsa, Pucholt Pascal, Rothwell Simon, Alexsson Andrei, Sandling Johanna K, Andersson Helena, Cooper Robert G, Padyukov Leonid, Tjärnlund Anna, Dastmalchi Maryam, Meadows Jennifer R S, Pyndt Diederichsen Louise, Molberg Øyvind, Chinoy Hector, Lamb Janine A, Rönnblom Lars, Lindblad-Toh Kerstin, Lundberg Ingrid E
Abstract excerpt
OBJECTIVE: Idiopathic inflammatory myopathies (IIMs) are a heterogeneous group of complex autoimmune conditions characterized by inflammation in skeletal muscle and extramuscular compartments, and interferon (IFN) system activation. We undertook this study to examine the contribution of genetic variation to disease susceptibility and to identify novel avenues for research in IIMs. METHODS: Targeted DNA sequencing...
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