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Article

New developments in genetics of myositis.

Current opinion in rheumatology - 1 Nov 2016

Rothwell Simon, Lamb Janine A, Chinoy Hector

Abstract excerpt

PURPOSE OF REVIEW: This article reviews the advances that have been made in our understanding of the genetics of the idiopathic inflammatory myopathies (IIM) in the past 2 years, with a particular focus on polymyositis, dermatomyositis and inclusion body myositis. RECENT FINDINGS: Two large human leukocyte antigen (HLA) imputation studies have confirmed a strong association with the 8.1 ancestral haplotype in...

Topics

Autoimmune Diseases
Dermatomyositis
Genetic Predisposition to Disease
Genome-Wide Association Study
HLA Antigens
Haplotypes
Humans
Myositis
Myositis, Inclusion Body
Polymyositis
Risk Factors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 27466937
DOI: 10.1097/BOR.0000000000000328

Genes

BLK
PTPN22
STAT4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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New developments in genetics of myositis.PMID 27466937Read ↗

The Genetics of Autoimmune MyositisSemantic proximity Read ↗

Dense genotyping of immune-related loci in idiopathic inflammatory myopathies confirms HLA alleles as the strongest genetic risk factor and suggests different genetic background for major clinical subgroups.Semantic proximity Read ↗

Strategies for evaluating idiopathic inflammatory myopathy disease susceptibility genes.Semantic proximity Read ↗

New Developments in the Genetics of Inclusion Body Myositis.Semantic proximity Read ↗

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Immune-Array Analysis in Sporadic Inclusion Body Myositis Reveals HLA-DRB1 Amino Acid Heterogeneity Across the Myositis Spectrum.Semantic proximity Read ↗

Risk factors and disease mechanisms in myositis.Semantic proximity Read ↗

Discovery of new myositis genetic associations through leveraging other immune-mediated diseases.Semantic proximity Read ↗

Entering a new phase of immunogenetics in the idiopathic inflammatory myopathies.Semantic proximity Read ↗

Genome-wide association study identifies HLA 8.1 ancestral haplotype alleles as major genetic risk factors for myositis phenotypes.Semantic proximity Read ↗

Identification of Novel Associations and Localization of Signals in Idiopathic Inflammatory Myopathies Using Genome-Wide Imputation.Semantic proximity Read ↗

Immunogenetics of Idiopathic Inflammatory Myopathies: The Role of HLA Genes Within and Beyond the Ancestral Haplotype.Semantic proximity Read ↗

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