Article
Immunogenetic risk and protective factors for the idiopathic inflammatory myopathies: distinct HLA-A, -B, -Cw, -DRB1 and -DQA1 allelic profiles and motifs define clinicopathologic groups in caucasians.
Medicine - 1 Nov 2005
O'Hanlon Terrance P, Carrick Danielle Mercatante, Arnett Frank C, Reveille John D, Carrington Mary, Gao Xiaojiang, Oddis Chester V, Morel Penelope A, Malley James D, Malley Karen, Dreyfuss Jonathan, Shamim Ejaz A, Rider Lisa G, Chanock Stephen J, Foster Charles B, Bunch Thomas, Plotz Paul H, Love Lori A, Miller Frederick W
Abstract excerpt
The idiopathic inflammatory myopathies (IIM) are systemic connective tissue diseases in which autoimmune pathology is suspected to promote chronic muscle inflammation and weakness. We have performed low to high resolution genotyping to characterize the allelic profiles of HLA-A, -B, -Cw, -DRB1, and -DQA1 loci in a large population of North American Caucasian patients with IIM representing the major...
Topics
- Adult
- Alleles
- Biomarkers
- Case-Control Studies
- Disease Susceptibility
- Female
- Genetic Variation
- HLA-B Antigens
- HLA-C Antigens