Immune-Array Analysis in Sporadic Inclusion Body Myositis Reveals HLA-DRB1 Amino Acid Heterogeneity Across the Myositis Spectrum.

doi:10.1002/art.40045

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Article

Immune-Array Analysis in Sporadic Inclusion Body Myositis Reveals HLA-DRB1 Amino Acid Heterogeneity Across the Myositis Spectrum.

Arthritis & rheumatology (Hoboken, N.J.) - 1 May 2017

Rothwell Simon, Cooper Robert G, Lundberg Ingrid E, Gregersen Peter K, Hanna Michael G, Machado Pedro M, Herbert Megan K, Pruijn Ger J M, Lilleker James B, Roberts Mark, Bowes John, Seldin Michael F, Vencovsky Jiri, Danko Katalin, Limaye Vidya, Selva-O'Callaghan Albert, Platt Hazel, Molberg Øyvind, Benveniste Olivier, Radstake Timothy R D J, Doria Andrea, De Bleecker Jan, De Paepe Boel, Gieger Christian, Meitinger Thomas, Winkelmann Juliane, Amos Christopher I, Ollier William E, Padyukov Leonid, Lee Annette T, Lamb Janine A, Chinoy Hector

Abstract excerpt

OBJECTIVE: Inclusion body myositis (IBM) is characterized by a combination of inflammatory and degenerative changes affecting muscle. While the primary cause of IBM is unknown, genetic factors may influence disease susceptibility. To determine genetic factors contributing to the etiology of IBM, we conducted the largest genetic association study of the disease to date, investigating immune-related genes using the...

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PMID: 28086002
DOI: 10.1002/art.40045
PMCID: PMC5516174

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CCR5

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